Variant Interpretation in Current Pharmacogenetic Testing

Current pharmacogenetic developments in oral anticoagulation therapy: the influence of variant VKORC1 and CYP2C9 alleles.

For decades coumarins have been the most commonly prescribed drugs for therapy and prophylaxis of thromboembolic conditions. Despite the limitation of their narrow therapeutic dosage window, the broad variation of intra- and inter-individual drug requirement, and the relatively high incidence of bleeding complications, prescriptions for coumarins are increasing due to the aging populations in i...

Pharmacogenetic Testing-An Unfulfilled Promise.

The Human Genome Project heralded great hope that the clinical use of individual genetic information would result in improved care through treatments tailored to an individual patient’s genotype. Such treatment would presumably reveal individual susceptibility to chronic diseases, thus preventing them, and lead to targeted pharmacotherapies based on an individual’s metabolism and susceptibility...

Is pharmacogenetic CYP2D6 testing useful?

BACKGROUND Pharmacogenetic testing is used to uncover genetic causes for variations in drug response. Documentation of the method's usefulness in a clinical setting is scarce. The aim of the study was to systematically categorize the experience from routine CYP2D6 genotyping in a diagnostic laboratory. MATERIAL AND METHODS All samples submitted to our laboratory for CYP2D6 genotyping in the p...

Pharmacogenetic testing in population of South Ural.

BACKGROUND Drug resistance is a phenomenon that has received serious attention in recent years in everyday medical practice. This may also be described as responsiveness or non-responsiveness to drugs, as patients respond partially to medical treatment or have no response at all [1]. The non-responsiveness to clopidogrel in cardiac patients of different populations is due to genetic variations ...

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN